Safety Evaluation of a New Traditional Chinese Medical Formula, Ciji-Hua’ai-Baosheng II Formula, in Adult Rodent Models
Table 5
Weekly Food intake dose (g) changes of rats treated with CHB-II-F in sub-chronic toxicity test.
Group
Dose (g/kg)
Time
Week
Week
Week
Week
Week
Week
Male
Control
0
154.66±12.02
181.59±7.79
161.35±10.01
159.98±13.21
163.56±7.33
165.55±9.73
CHB-II-F (H)
26.20
148.78±8.11
168.48±11.13
161.07±9.15
145.79±14.13
181.70±9.47
169.07±11.81
CHB-II-F (M)
13.10
138.91±2.12
168.97±8.31
131.32±7.56
139.87±6.16
131.39±10.02
160.18±5.72
CHB-II-F (L)
6.55
150.58±7.97
180.52±6.75
128.17±12.33
127.11±3.37
163.49±9.19
176.13±6.11
Female
Control
0
109.90±7.21
132.94±3.66
109.60±8.04
118.81±11.42
120.90±7.15
113.43±9.30
CHB-II-F (H)
26.20
119.80±3.37
126.30±10.60
125.57±9.9
197.13±6.65
134.80±3.09
126.69±8.57
CHB-II-F (M)
13.10
107.65±6.67
126.23±6.67
98.28±6.70
119.79±8.93
120.04±6.01
112.70±8.70
CHB-II-F (L)
6.55
108.00±3.63
89.70±6.77
109.92±3.36
110.45±3.04
120.57±3.56
115.41±11.05
Note: Data were presented as the mean ±SD from 12 rats after the former 4 weeks and 6 rats after the later 2 weeks. No statistically significant differences were found (P > 0.05).
