Safety Evaluation of a New Traditional Chinese Medical Formula, Ciji-Hua’ai-Baosheng II Formula, in Adult Rodent Models

Table 8

ROW indices (g/g) of rats treated with CHB-II-F for 4 weeks in the sub-chronic toxicity test.

Organ	Dose (g/kg)
	Control	26.20	13.10	6.55
Male
Brain	0.58±0.04	0.72±0.15	0.54±0.05	0.56±0.02
Heart	0.28±0.02	0.42±0.09	0.34±0.03	0.31±0.02
Liver	2.69±0.23	2.72±0.06	2.46±0.08	2.35±0.11
Spleen	0.20±0.02	0.25±0.03	0.18±0.02	0.20±0.01
Lung	0.63±0.09	0.75±0.15	0.85±0.36	0.69±0.15
Kidney	0.64±0.03	0.66±0.02	0.65±0.04	0.63±0.03
Thymus	0.13±0.01	0.18±0.04	0.16±0.04	0.15±0.03
Adrenal glands	0.02±0.02	0.02±0.01	0.02±0.03	0.02±0.01
Testes	0.50±0.04	0.51±0.03	0.53±0.05	0.46±0.03
Epididymis	0.13±0.02	0.13±0.01	0.11±0.04	0.13±0.02
bladder	0.05±0.05	0.06±0.03	0.04±0.01	0.04±0.01
Female
Brain	0.78±0.03	0.79±0.03	0.82±0.02	0.79±0.02
Heart	0.32±0.02	0.31±0.02	0.32±0.02	0.29±0.02
Liver	2.77±0.14	2.67±0.06	2.85±0.12	2.85±0.13
Spleen	0.24±0.03	0.22±0.02	0.27±0.03	0.29±0.02
Lung	0.70±0.05	0.93±0.15	0.61±0.04	0.85±0.26
Kidney	0.67±0.51	0.62±0.03	0.63±0.01	0.63±0.02
Thymus	0.19±0.03	0.19±0.04	0.13±0.01	0.16±0.04
Adrenal glands	0.03±0.05	0.03±0.03	0.03±0.04	0.03±0.01
Uterus	0.13±0.01	0.14±0.02	0.15±0.01	0.14±0.01
Ovary	0.03±0.01	0.04±0.01	0.03±0.01	0.04±0.01
bladder	0.06±0.01	0.06±0.01	0.06±0.02	0.07±0.02

Note: Data were presented as the mean ±SD from 12 rats. Statistical analysis: P < 0.05, P < 0.01 compared with control group (untreated controls).