Da-Cheng-Qi Decoction Alleviates Intestinal Injury in Rats with Severe Acute Pancreatitis by Inhibiting the JAK2-STAT3 Signaling Pathway

Table 3

Comparisons of the dynamic IL-6 levels.

Group	3 hours	6 hours	12 hours	18 hours
SO	25.45 ± 6.13	32.05 ± 7.64^★	29.09 ± 7.87^★	28.91 ± 8.79
SAP	89.87 ± 16.37^♀	151.08 ± 15.37^▲♂	213.29 ± 19.59^▲☆	184.70 ± 15.86^▲◎
R	57.06 ± 22.85^♀	128.34 ± 19.93^■♂	180.66 ± 29.31^■☆	164.79 ± 29.48^■◎
S	64.53 ± 19.74^♀	139.86 ± 21.69^•♂	199.57 ± 27.04^•☆	177.02 ± 27.83^•◎
DCQD	50.59 ± 22.57^♀	120.82 ± 20.15^◢♂	168.15 ± 24.86^◢☆	141.30 ± 23.80^◢◎

Note: The data are presented as pg/mL. ^★In the SO group, 3 hours versus 6 hours and 6 hours versus 12 hours are significantly different (). ^▲In the SAP group, 3 hours versus 6 hours, 6 hours versus 12 hours, and 12 hours versus 18 hours are significantly different (). ^■In the R group, 3 hours versus 6 hours, 6 hours versus 12 hours, and 12 hours versus 18 hours are significantly different (). ^•In the S group, 3 hours versus 6 hours, 6 hours versus 12 hours, and 12 hours versus 18 hours are significantly different ().^◢In the DCQD group, 3 hours versus 6 hours, 6 hours versus 12 hours, and 12 hours versus 18 hours are significantly different (). ^♀At 3 hours, the SO group versus the SAP group, the SAP group versus the R group, the R group versus the S group, and the S group versus the DCQD group are significantly different. ^♂At 6 hours, the SO group versus the SAP group, the SAP group versus the R group, the R group versus the S group, and the S group versus the DCQD group are significantly different. ^☆At 12 hours, the SO group versus the SAP group, the SAP group versus the R group, the R group versus the S group, and the S group versus the DCQD group are significantly different. ^◎At 18 hours, the SO group versus the SAP group, the SAP group versus the R group, the R group versus the S group, and the S group versus the DCQD group are significantly different. DCQD, Da-Cheng-Qi decoction; GAPDH, glyceraldehyde-3-phosphate dehydrogenase; IL-4, interleukin 4; IL-6, interleukin 6; IL-10 interleukin 10; JAK2, Janus kinase 2; p-JAK2, phosphorylated Janus kinase 2; p-STAT3, phosphorylated signal transducers and transcription 3; R, ruxolitinib-treated rats with severe acute pancreatitis; S, Stattic-treated rats with severe acute pancreatitis; SAP, severe acute pancreatitis; SO, sham operation; STAT3, signal transducers and transcription 3; TNF-α, tumor necrosis factor alpha.