Evidence-Based Complementary and Alternative Medicine / 2019 / Article / Tab 4

Research Article

Da-Cheng-Qi Decoction Alleviates Intestinal Injury in Rats with Severe Acute Pancreatitis by Inhibiting the JAK2-STAT3 Signaling Pathway

Table 4

Comparisons of the dynamic IL-4 levels.

Group3 hours6 hours12 hours18 hours

SO12.99 ± 2.6116.97 ± 4.3713.58 ± 3.9312.49 ± 3.21
SAP31.29 ± 8.5945.08 ± 15.37▲♂58.85 ± 9.34▲☆50.65 ± 11.06▲◎
R23.79 ± 11.3534.09 ± 14.03■♂45.89 ± 16.95■☆38.47 ± 13.06■◎
S28.09 ± 12.1740.65 ± 13.85•♂50.19 ± 15.87•☆41.02 ± 13.29•◎
DCQD20.73 ± 9.2031.37 ± 12.71◢♂39.87 ± 15.00◢☆31.85 ± 12. 71◢◎

Note: The data are presented as pg/mL. In the SO group, 3 hours versus 6 hours and 6 hours versus 12 hours are significantly different (). In the SAP group, 3 hours versus 6 hours, 6 hours versus 12 hours, and 12 hours versus 18 hours are significantly different (). In the R group, 3 hours versus 6 hours, 6 hours versus 12 hours, and 12 hours versus 18 hours are significantly different (). In the S group, 3 hours versus 6 hours, 6 hours versus 12 hours, and 12 hours versus 18 hours are significantly different ().In the DCQD group, 3 hours versus 6 hours, 6 hours versus 12 hours, and 12 hours versus 18 hours are significantly different (). At 3 hours, the SO group versus the SAP group, the SAP group versus the R group, the R group versus the S group, and the S group versus the DCQD group are significantly different. At 6 hours, the SO group versus the SAP group, the SAP group versus the R group, the R group versus the S group, and the S group versus the DCQD group are significantly different. At 12 hours, the SO group versus the SAP group, the SAP group versus the R group, the R group versus the S group, and the S group versus the DCQD group are significantly different. At 18 hours, the SO group versus the SAP group, the SAP group versus the R group, the R group versus the S group, and the S group versus the DCQD group are significantly different. DCQD, Da-Cheng-Qi decoction; GAPDH, glyceraldehyde-3-phosphate dehydrogenase; IL-4, interleukin 4; IL-6, interleukin 6; IL-10 interleukin 10; JAK2, Janus kinase 2; p-JAK2, phosphorylated Janus kinase 2; p-STAT3, phosphorylated signal transducers and transcription 3; R, ruxolitinib-treated rats with severe acute pancreatitis; S, Stattic-treated rats with severe acute pancreatitis; SAP, severe acute pancreatitis; SO, sham operation; STAT3, signal transducers and transcription 3; TNF-α, tumor necrosis factor alpha.

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