Evidence-Based Complementary and Alternative Medicine / 2019 / Article / Tab 5

Research Article

Da-Cheng-Qi Decoction Alleviates Intestinal Injury in Rats with Severe Acute Pancreatitis by Inhibiting the JAK2-STAT3 Signaling Pathway

Table 5

Comparisons of the dynamic IL-10 levels.

Group3 hours6 hours12 hours18 hours

SO10.18 ± 3.0815.93 ± 4.2712.07 ± 4.0111.29 ± 3.77
SAP28.31 ± 9.9141.01 ± 12.08▲♂50.11 ± 11.89▲☆44.47 ± 11.56▲◎
R21.00 ± 11.2835.57 ± 13.13■♂46.19 ± 14.35■☆38.47 ± 12.16■◎
S18.14 ± 10.1932.24 ± 12.57•♂40.11 ± 12.34•☆34.52 ± 11.25•◎
DCQD15.80 ± 7.6125.57 ± 12.01◢♂39.07 ± 14.01◢☆31.85 ± 12. 11◢◎

Note: The data are presented as pg/mL. In the SO group, 3 hours versus 6 hours and 6 hours versus 12 hours are significantly different (). In the SAP group, 3 hours versus 6 hours, 6 hours versus 12 hours, and 12 hours versus 18 hours are significantly different (). In the R group, 3 hours versus 6 hours, 6 hours versus 12 hours, and 12 hours versus 18 hours are significantly different (). In the S group, 3 hours versus 6 hours, 6 hours versus 12 hours, and 12 hours versus 18 hours are significantly different ().In the DCQD group, 3 hours versus 6 hours, 6 hours versus 12 hours, and 12 hours versus 18 hours are significantly different (). At 3 hours, the SO group versus the SAP group, the SAP group versus the R group, the R group versus the S group, and the S group versus the DCQD group are significantly different. At 6 hours, the SO group versus the SAP group, the SAP group versus the R group, the R group versus the S group, and the S group versus the DCQD group are significantly different. At 12 hours, the SO group versus the SAP group, the SAP group versus the R group, the R group versus the S group, and the S group versus the DCQD group are significantly different. At 18 hours, the SO group versus the SAP group, the SAP group versus the R group, the R group versus the S group, and the S group versus the DCQD group are significantly different. DCQD, Da-Cheng-Qi decoction; GAPDH, glyceraldehyde-3-phosphate dehydrogenase; IL-4, interleukin 4; IL-6, interleukin 6; IL-10 interleukin 10; JAK2, Janus kinase 2; p-JAK2, phosphorylated Janus kinase 2; p-STAT3, phosphorylated signal transducers and transcription 3; R, ruxolitinib-treated rats with severe acute pancreatitis; S, Stattic-treated rats with severe acute pancreatitis; SAP, severe acute pancreatitis; SO, sham operation; STAT3, signal transducers and transcription 3; TNF-α, tumor necrosis factor alpha.

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