Evidence-Based Complementary and Alternative Medicine / 2019 / Article / Tab 7

Research Article

Da-Cheng-Qi Decoction Alleviates Intestinal Injury in Rats with Severe Acute Pancreatitis by Inhibiting the JAK2-STAT3 Signaling Pathway

Table 7

Comparisons of the protein expression of p-JAK2 in the terminal ileum.

Group3 hours6 hours12 hours18 hours

SO0.446 ± 0.0770.501 ± 0.0850.574 ± 0.0850.481 ± 0.095
SAP0.802 ± 0.178♀a0.991 ± 0.182▲♂a1.345 ± 0.246▲☆a0.921 ± 0.181▲◎a
R0.661 ± 0.1210.910 ± 0.133■♂1.174 ± 0.221■☆0.885 ± 0.204■◎
S0.775 ± 0.168♀a0.950 ± 0.142•♂a1.321 ± 0.233•☆a0.922 ± 0.185•◎a
DCQD0.671 ± 0.1270.935 ± 0.142◢♂1.211 ± 0.212◢☆0.851 ± 0.196◢◎

Note: The data are presented as the p-JAK2/GAPDH ratio. In the SO group, 3 hours versus 6 hours, 6 hours versus 12 hours, and 12 hours versus 18 hours are significantly different ().In the SAP group, 3 hours versus 6 hours, 6 hours versus 12 hours, and 12 hours versus 18 hours are significantly different (). In the R group, 3 hours versus 6 hours, 6 hours versus 12 hours, and 12 hours versus 18 hours are significantly different ().In the S group, 3 hours versus 6 hours, 6 hours versus 12 hours, and 12 hours versus 18 hours are significantly different ().In the DCQD group, 3 hours versus 6 hours, 6 hours versus 12 hours, and 12 hours versus 18 hours are significantly different (). At 3 hours, the SO group versus the SAP group, the SAP group versus the R group, the R group versus the S group, and the S group versus the DCQD group are significantly different. At 6 hours, the SO group versus the SAP group, the SAP group versus the R group, the R group versus the S group, and the S group versus the DCQD group are significantly different. At 12 hours, the SO group versus the SAP group, the SAP group versus the R group, the R group versus the S group, and the S group versus the DCQD group are significantly different. At 18 hours, the SO group versus the SAP group, the SAP group versus the R group, the R group versus the S group, and the S group versus the DCQD group are significantly different. aAt the same timepoints, the SAP group versus the S group are not significantly different (). DCQD, Da-Cheng-Qi decoction; GAPDH, glyceraldehyde-3-phosphate dehydrogenase; IL-4, interleukin 4; IL-6, interleukin 6; IL-10 interleukin 10; JAK2, Janus kinase 2; p-JAK2, phosphorylated Janus kinase 2; p-STAT3, phosphorylated signal transducers and transcription 3; R, ruxolitinib-treated rats with severe acute pancreatitis; S, Stattic-treated rats with severe acute pancreatitis; SAP, severe acute pancreatitis; SO, sham operation; STAT3, signal transducers and transcription 3; TNF-α, tumor necrosis factor alpha.

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