Da-Cheng-Qi Decoction Alleviates Intestinal Injury in Rats with Severe Acute Pancreatitis by Inhibiting the JAK2-STAT3 Signaling Pathway

Table 8

Comparisons of the protein expression of p-STAT3 in the pancreas.

Group	3 hours	6 hours	12 hours	18 hours
SO	0.302 ± 0.055	0.383 ± 0.060^★	0.412 ± 0.065^★	0.343 ± 0.056^★
SAP	0.621 ± 0.166^♀	0.877 ± 0.169^▲♂	1.131 ± 0.222^▲☆	0.871 ± 0.170^▲◎
R	0.570 ± 0.129^♀	0.734 ± 0.138^■♂	0.990 ± 0.191^■☆	0.741 ± 0.190^■◎
S	0.492 ± 0.107^♀	0.605 ± 0.124^•♂	0.851 ± 0.180^•☆	0.632 ± 0.127^•◎
DCQD	0.433 ± 0.094^♀	0.582 ± 0.121^◢♂	0.792 ± 0.196^◢☆	0.618 ± 0.121^◢◎

Note: The data are presented as the p-STAT3/GAPDH ratio. ^★In the SO group, 3 hours versus 6 hours, 6 hours versus 12 hours, and 12 hours versus 18 hours are significantly different (). ^▲In the SAP group, 3 hours versus 6 hours, 6 hours versus 12 hours, and 12 hours versus 18 hours are significantly different (). ^■In the R group, 3 hours versus 6 hours, 6 hours versus 12 hours, and 12 hours versus 18 hours are significantly different (). ^•In the S group, 3 hours versus 6 hours, 6 hours versus 12 hours, and 12 hours versus 18 hours are significantly different ().^◢In the DCQD group, 3 hours versus 6 hours, 6 hours versus 12 hours, and 12 hours versus 18 hours are significantly different (). ^♀At 3 hours, the SO group versus the SAP group, the SAP group versus the R group, the R group versus the S group, and the S group versus the DCQD group are significantly different. ^♂At 6 hours, the SO group versus the SAP group, the SAP group versus the R group, the R group versus the S group, and the S group versus the DCQD group are significantly different. ^☆At 12 hours, the SO group versus the SAP group, the SAP group versus the R group, the R group versus the S group, and the S group versus the DCQD group are significantly different. ^◎At 18 hours, the SO group versus the SAP group, the SAP group versus the R group, the R group versus the S group, and the S group versus the DCQD group are significantly different. DCQD, Da-Cheng-Qi decoction; GAPDH, glyceraldehyde-3-phosphate dehydrogenase; IL-4, interleukin 4; IL-6, interleukin 6; IL-10 interleukin 10; JAK2, Janus kinase 2; p-JAK2, phosphorylated Janus kinase 2; p-STAT3, phosphorylated signal transducers and transcription 3; R, ruxolitinib-treated rats with severe acute pancreatitis; S, Stattic-treated rats with severe acute pancreatitis; SAP, severe acute pancreatitis; SO, sham operation; STAT3, signal transducers and transcription 3; TNF-α, tumor necrosis factor alpha.