Evidence-Based Complementary and Alternative Medicine / 2019 / Article / Tab 8

Research Article

Da-Cheng-Qi Decoction Alleviates Intestinal Injury in Rats with Severe Acute Pancreatitis by Inhibiting the JAK2-STAT3 Signaling Pathway

Table 8

Comparisons of the protein expression of p-STAT3 in the pancreas.

Group3 hours6 hours12 hours18 hours

SO0.302 ± 0.0550.383 ± 0.0600.412 ± 0.0650.343 ± 0.056
SAP0.621 ± 0.1660.877 ± 0.169▲♂1.131 ± 0.222▲☆0.871 ± 0.170▲◎
R0.570 ± 0.1290.734 ± 0.138■♂0.990 ± 0.191■☆0.741 ± 0.190■◎
S0.492 ± 0.1070.605 ± 0.124•♂0.851 ± 0.180•☆0.632 ± 0.127•◎
DCQD0.433 ± 0.0940.582 ± 0.121◢♂0.792 ± 0.196◢☆0.618 ± 0.121◢◎

Note: The data are presented as the p-STAT3/GAPDH ratio. In the SO group, 3 hours versus 6 hours, 6 hours versus 12 hours, and 12 hours versus 18 hours are significantly different (). In the SAP group, 3 hours versus 6 hours, 6 hours versus 12 hours, and 12 hours versus 18 hours are significantly different (). In the R group, 3 hours versus 6 hours, 6 hours versus 12 hours, and 12 hours versus 18 hours are significantly different (). In the S group, 3 hours versus 6 hours, 6 hours versus 12 hours, and 12 hours versus 18 hours are significantly different ().In the DCQD group, 3 hours versus 6 hours, 6 hours versus 12 hours, and 12 hours versus 18 hours are significantly different (). At 3 hours, the SO group versus the SAP group, the SAP group versus the R group, the R group versus the S group, and the S group versus the DCQD group are significantly different. At 6 hours, the SO group versus the SAP group, the SAP group versus the R group, the R group versus the S group, and the S group versus the DCQD group are significantly different. At 12 hours, the SO group versus the SAP group, the SAP group versus the R group, the R group versus the S group, and the S group versus the DCQD group are significantly different. At 18 hours, the SO group versus the SAP group, the SAP group versus the R group, the R group versus the S group, and the S group versus the DCQD group are significantly different. DCQD, Da-Cheng-Qi decoction; GAPDH, glyceraldehyde-3-phosphate dehydrogenase; IL-4, interleukin 4; IL-6, interleukin 6; IL-10 interleukin 10; JAK2, Janus kinase 2; p-JAK2, phosphorylated Janus kinase 2; p-STAT3, phosphorylated signal transducers and transcription 3; R, ruxolitinib-treated rats with severe acute pancreatitis; S, Stattic-treated rats with severe acute pancreatitis; SAP, severe acute pancreatitis; SO, sham operation; STAT3, signal transducers and transcription 3; TNF-α, tumor necrosis factor alpha.

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