Evidence on Integrating Pharmacokinetics to Find Truly Therapeutic Agent for Alzheimer’s Disease: Comparative Pharmacokinetics and Disposition Kinetics Profiles of Stereoisomers Isorhynchophylline and Rhynchophylline in Rats

Table 1

Regression equations, linearity ranges, and correlation coefficients of the calibration curves.

Analyte	Biological specimen	Regression equation	Linear ranges (ng/mL)	Correlation coefficient
IRN	Brain	y = 0.2100x + 0.0016	0.1–5.0	0.9996
	CSF	y = 0.3187x + 0.0042	0.1–5.0	0.9994
	Plasma	y = 0.7395x – 0.0137	1.0–50.0	0.9991
RN	Brain	y = 1.5308x + 0.0081	0.5–10.0	0.9992
		y = 1.5308x + 0.0081	0.1–5.0	0.9991
	CSF	y = 1.3104x – 0.0124	0.5–10.0	0.9994
		y = 1.3029x – 0.0002	0.1–5.0	0.9991
	Plasma	y = 1.4469x – 0.2262	25.0–500.0	0.9992
		y = 0.6529x + 0.1385	1.0–50.0	0.9996