Prophylactic Repetitive Treatment with the Herbal Medicine Kei-kyoh-zoh-soh-oh-shin-bu-toh Attenuates Oxaliplatin-Induced Mechanical Allodynia by Decreasing Spinal Astrocytes

Figure 4

Effect of prophylactic repetitive oral administration of Kei-kyoh-zoh-soh-oh-shin-bu-toh (KSOT) on cold dysesthesia induced by oxaliplatin. Mice were given a single injection of oxaliplatin (OXP, 3 mg/kg, i.p.) or the corresponding vehicle (VH1) on day 0. KSOT or the vehicle (VH2) was orally administered once daily, starting the day after a single injection of oxaliplatin or the corresponding vehicle (VH1). Cold dysesthesia was evaluated using acetone test. Data are presented as mean ± standard errors of the mean (n = 6). P < 0.05 vs. VH1 + VH2 (Holm-Šidák multiple comparisons). i.p.: intraperitoneal injection.