Curcumin Inhibits Joint Contracture through PTEN Demethylation and Targeting PI3K/Akt/mTOR Pathway in Myofibroblasts from Human Joint Capsule

<div>Myofibroblasts were treated with curcumin. Curcumin restored PTEN expression, downregulated <i>α</i>-SMA expression, and suppressed the proliferation and migration of myofibroblasts by demethylation and inhibition of PI3K/Akt/mTOR signaling.</div>

Evidence-Based Complementary and Alternative Medicine

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Figure 6

Figure 6: Curcumin Inhibits Joint Contracture through PTEN Demethylation and Targeting PI3K/Akt/mTOR Pathway in Myofibroblasts from Human Joint Capsule 

Figure 6 | Curcumin Inhibits Joint Contracture through PTEN Demethylation and Targeting PI3K/Akt/mTOR Pathway in Myofibroblasts from Human Joint Capsule 