Molecular Changes in Diabetic Wound Healing following Administration of Vitamin D and Ginger Supplements: Biochemical and Molecular Experimental Study
Table 2
Effect of vitamin D and gingerols fraction supplements on wound contraction and epithelialization period of wound in excision wound model.
Group
Wound contraction
Epithelialization period (days)
0 day
3rd day
6th day
9th day
Scar area (mm2)
Control
196.1 ± 0.45
156.2± 0.2 (25%)
96.7 ± 3.7 (48%)
86.4 ±1.6 (68%)
93.4±2.5
14.6 ± 0.45
Diabetes
198.7 ± 0.6
185±2.1 (16.9 %)
112.3± 1.2 (29.2 %)
108 ±3.8 (52.5 %)
78.3±3.2
18.8 ± 0.65
Vitamin D
196.6 ± 0.65
128.3±2.3 (39.6%)
75 ± 3.6 (71 %)
65 ±4.8 (86.5%)
96.8±3.1
13.0± 0.52
GF
198.6 ± 0.56
115 ± 2.1 (42 %)
61± 1.1 (81.8%)
35.4 ±0.4 (92.6 %)
98.6±1.4
12.0 ± 0.35
GF+VitaminD
197.9 ± 0.98
102 ± 0.31 (51.4 %)
56 ± 3.1 (87.5 %)
26.4 ±0.3 (96%)
89.3±2.3
11.3 ± 2.3
P < 0.05, P < 0.01, and P < 0.001. All values are represented as mean ± SD, = 12, animals in each group. Data were analyzed by one-way ANOVA, followed by Tukey-Kramer Multiple Comparisons Test. GF: gingerols fraction group.
