Molecular Changes in Diabetic Wound Healing following Administration of Vitamin D and Ginger Supplements: Biochemical and Molecular Experimental Study
Table 3
Correlation between circulating miRNAs expression with fibrogenic markers (HPX, collagen, and fibronectin), diabetic controls, and wound healing of diabetic skin wound tissues of mice following treatment with gingerols fraction and/or vitamin D for three weeks.
Variables
Whole cohort (qRT-PCR) of miRNAs concentrations
miR-146a
miR-155
miR-15 a
R
P
R
P
R
P
HPX (g/g of tissues)
0.52
0.001
0.22
0.001
0.57
0.001
Collagen
0.31
0.001
0.39
0.001
0.49
0.001
Fibronectin
0.25
0.001
0.31
0.001
0.35
0.001
Diabetes ( HbA1c)
-0.46
0.001
-0.51
0.001
-0.54
0.001
Insulin
-0.39
0.001
-0.31
0.001
-0.38
0.001
C-peptide (ng/mL)
-0.23
0.001
-0.42
0.001
-0.53
0.001
Epithelialization period (days)
0.47
0.01
0.33
0.03
0.41
0.01
wound closer (% contraction)
0.25
0.01
0.48
0.01
0.52
0.01
Scar formation
0.26
0.01
0.21
0.01
0.32
0.01
Data are R (Spearman). HbA1C: glycated hemoglobin A1c, miR: microRNA, and HPX: hydroxyproline.
