Anticholinesterase and Antioxidant Potential of Hydromethanolic Extract of <i>Ziziphus mucronata</i> (Rhamnaceae) Leaves on Scopolamine-Induced Memory and Cognitive Dysfunctions in Mice

<div>Effect of the hydromethanolic extract of <i>Z. mucronata</i> administration on the concentration of MDA. Data were analysed using one-way ANOVA followed by Tukey’s posttest. Each column represents mean ± S.E.M. of 6 animals. <svg height="13.532pt" id="M24" style="vertical-align:-3.4295pt" version="1.1" viewbox="-0.0498162 -10.1025 56.1861 13.532" width="56.1861pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.0091,0,0,-0.0091,0,-5.741)"><path d="M486 158C486 177 478 202 466 220C413 228 386 236 336 262C386 288 413 297 466 304C478 323 486 347 485 366C470 376 444 381 422 380C389 338 368 319 321 288C323 345 329 372 349 422C339 442 322 461 305 470C289 461 271 442 262 422C281 372 287 345 290 288C243 319 222 338 189 380C167 381 142 376 125 366C125 347 133 322 145 304C198 296 225 288 275 262C225 236 198 227 145 220C133 201 125 177 126 158C141 148 167 143 189 144C222 186 243 205 290 236C288 179 282 152 262 102C272 82 289 63 306 54C322 63 340 82 350 102C330 152 324 179 321 236C368 205 390 186 422 144C444 143 470 148 486 158Z"></path></g><g transform="matrix(.0091,0,0,-0.0091,5.56,-5.741)"><path d="M486 158C486 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613 172 594 109 583V559L157 557C201 555 205 550 205 499V114C205 42 199 34 109 27V0H384Z"></path></g></svg> and when compared with the scopolamine-treated group. <svg height="15.6876pt" id="M25" style="vertical-align:-3.4294pt" version="1.1" viewbox="-0.0498162 -12.2582 56.0831 15.6876" width="56.0831pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.0091,0,0,-0.0091,0,-5.741)"><path d="M501 517C491 587 426 710 310 710C240 710 175 662 175 601C175 561 201 517 250 452C219 438 187 423 157 404C88 360 24 280 24 178C24 71 90 -12 195 -12C250 -12 297 6 334 32C412 87 452 170 452 249C452 335 408 396 333 481C259 565 229 601 229 621C229 642 245 652 275 652C359 652 427 583 490 499L501 517ZM364 233C364 142 323 33 222 33C173 33 119 81 119 178C119 265 156 335 193 374C213 395 242 413 272 425C308 384 364 319 364 233Z"></path></g><g transform="matrix(.013,0,0,-0.013,5.294,0)"><path d="M570 304C570 398 525 448 414 448C385 448 343 445 312 434L329 511L321 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35 457 35 312C35 153 89 -12 240 -12C390 -12 443 166 443 312C443 466 390 635 241 635ZM238 602C329 602 354 454 354 312C354 172 330 22 240 22C152 22 124 173 124 313S148 602 238 602Z"></path></g><g transform="matrix(.013,0,0,-0.013,43.342,0)"><path d="M241 635C89 635 35 457 35 312C35 153 89 -12 240 -12C390 -12 443 166 443 312C443 466 390 635 241 635ZM238 602C329 602 354 454 354 312C354 172 330 22 240 22C152 22 124 173 124 313S148 602 238 602Z"></path></g><g transform="matrix(.013,0,0,-0.013,49.582,0)"><path d="M384 0V27C293 34 287 42 287 114V635C232 613 172 594 109 583V559L157 557C201 555 205 550 205 499V114C205 42 199 34 109 27V0H384Z"></path></g></svg> vs. control group. Scopolamine was administered in the later half for 7 days.</div>

Evidence-Based Complementary and Alternative Medicine

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Figure 8

Figure 8: Anticholinesterase and Antioxidant Potential of Hydromethanolic Extract of <i>Ziziphus mucronata</i> (Rhamnaceae) Leaves on Scopolamine-Induced Memory and Cognitive Dysfunctions in Mice 

Figure 8 | Anticholinesterase and Antioxidant Potential of Hydromethanolic Extract of Ziziphus mucronata (Rhamnaceae) Leaves on Scopolamine-Induced Memory and Cognitive Dysfunctions in Mice 