The Effect of Acupoint Application of Sinomenine for Rheumatoid Arthritis Measured by Microdialysis and UPLC-MS/MS

Table 2

Pharmacokinetic/pharmacodynamic parameters of arginine and citrulline in four administration routes.

PK/PD parameters	Arginine				Citrulline
	ST 36	GB 34	Knee joint	Oral	ST 36	GB 34	Knee joint	Oral
Emax (%)	84.7	79.91	65.9	83.42	80.29	57.22	78.69	78.36
ECe50	246.77	181.56	169.89	357.43	195.89	307.4	113.5	207.53
ke0	0.6	0.69	0.67	0.74	0.6	0.66	0.7	0.72