Effect of Naoxintong Capsules on the Activities of CYP450 and Metabolism of Metoprolol Tartrate in Rats Evaluated by Probe Cocktail and Pharmacokinetic Methods

<table class="table-group" id="tab2"><tr><td><table class="table"><tr><td class="thead-hr" colspan="5"><hr/></td></tr><tr class="thead"><td class="align_left">Analyses</td><td class="align_center">Precursor ion (<i>m</i>/<i>z</i>)</td><td class="align_center">Product ion (<i>m</i>/<i>z</i>)</td><td class="align_center">Fragmentor (V)</td><td class="align_center">CE (V)</td></tr><tr><td class="thead-hr" colspan="5"><hr/></td></tr><tr><td class="align_left">Metoprolol tartrate</td><td class="align_center">268.2</td><td class="align_center">121.1</td><td class="align_center">110</td><td class="align_center">20</td></tr><tr><td class="align_left"><i>α</i>-Hydroxymetoprolol</td><td class="align_center">284.2</td><td class="align_center">116.1</td><td class="align_center">120</td><td class="align_center">14</td></tr><tr><td class="align_left">O-demethylmetoprolol</td><td class="align_center">254.2</td><td class="align_center">116.1</td><td class="align_center">110</td><td class="align_center">23</td></tr><tr><td class="align_left">Propranolol hydrochloride (IS)</td><td class="align_center">260.2</td><td class="align_center">155.1</td><td class="align_center">90</td><td class="align_center">23</td></tr><tr class="table-tr"><td colspan="5"><hr class="tbody-hr"/></td></tr></table></td></tr></table>

<div>Mass spectra properties of the target ingredients.</div>

Evidence-Based Complementary and Alternative Medicine

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Table 2

Table 2: Effect of Naoxintong Capsules on the Activities of CYP450 and Metabolism of Metoprolol Tartrate in Rats Evaluated by Probe Cocktail and Pharmacokinetic Methods 

Table 2 | Effect of Naoxintong Capsules on the Activities of CYP450 and Metabolism of Metoprolol Tartrate in Rats Evaluated by Probe Cocktail and Pharmacokinetic Methods 