Research Article
Study on the Antihypertensive Mechanism of Astragalus membranaceus and Salvia miltiorrhiza Based on Intestinal Flora-Host Metabolism
Table 3
Correlation between potential biomarkers and differential flora (Rho value / P value).
| | ā | Akkermansia | Lactobacillus intestinalis | Akkermansia muciniphila | Rumen bacterium NK4A214 | Lachnoclostridium | Faecalibaculum | Lactobacillus reuteri | Clostridium sp. MC 40 |
| | Taurocholic acid | 0.605/0.013 | 0.653/0.0 | 0.607/0.013 | -0.385/0.141 | 0.094/0.729 | 0.462/0.072 | 0.556/0.025 | -0.441/0.088 | | L-Kynurenine | 0.330/0.212 | 0.515/0.017 | 0.314/0.008 | -0.579/0.154 | 0.753/0.001 | 0.691/0.003 | 0.582/0.018 | -0.758/0/0007 | | 5-Hydroxyindoleacetic acid | 0.639/0.008 | 0.709/0.002 | 0.651/0.006 | -0.391/0.134 | 0.432/0.094 | 0.224/0.405 | 0.218/0.418 | -0,276/0.3 | | Indoleacetic acid | -0.728/0.001 | -0.829/0.00007 | -0.729/0.001 | 0.55/0.027 | -0.679/0.004 | -0.671/0.004 | -0.559/0.024 | 0.73/0.001 | | 4-Pyridoxic acid | 0.265/0.321 | 0.459/0.074 | 0.242/0.367 | -0.482/0.058 | 0.715/0.002 | 0.662/0.005 | 0.568/0.0022 | -0.729/0.001 | | Adrenic acid | -0.509/0.044 | -0.638/0.008 | -0.520/0.039 | 0.588/0.017 | -0.662/0.005 | -0.482/0.058 | -0.524/0.037 | 0.56/0.024 | | Arachidonic acid | -0.437/0.090 | -0.388/0.137 | -0.436/0.091 | 0.368/0.161 | -0.75/0.001 | -0.518/0.040 | -0.594/0.015 | 0.699/0.003 | | Prostaglandin E2 | -0.631/0.009 | -0.709/0.002 | -0.617/0.011 | 0.4/0.125 | -0.641/0.007 | -0.641/0.007 | -0.685/0.003 | 0.736/0.001 | | Leukotriene B4 | -0.681/0.004 | -0.676/0.004 | -0.679/0.004 | 0.359/0.172 | -0.741/0.001 | -0.635/0.008 | -0.774/0.0004 | 0.677/0.004 | | Gamma-Aminobutyric acid | 0.453/0.078 | 0.415/0.110 | 0.476/0.063 | -0.379/0.147 | 0.579/0.019 | 0.403/0.122 | 0.344/0.192 | -0.504/0.046 | | Sphinganine 1-phosphate | 0.260/0.330 | 0.674/0.004 | 0.264/0.324 | -0.3/0.259 | 0.624/0.010 | 0.485/0.057 | 0.568/0.022 | -0.582/0.018 | | Glycine | 0.471/0.066 | 0.435/0.092 | 0.474/0.063 | -0.282/0.289 | 0.518/0.040 | 0.241/0.368 | 0.321/0.226 | -0.415/0.11 | | Cortisone | -0.472/0.065 | -0.547/0.028 | -0.467/0.068 | 0.485/0.057 | -0.45/0.080 | -0.25/0.350 | -0.35/0.184 | 0.554/0.026 | | Testosterone | -0.726/0.001 | -0.471/0.066 | -0.726/0.001 | 0.35/0.184 | -0.721/0.002 | -0.697/0.003 | -0.715/0.002 | 0.782/0.0003 | | Beta-Estradiol | 0.506/0.045 | 0.738/0.001 | 0.508/0.044 | -0.3/0.259 | 0.438/0.090 | 0.362/0.169 | 0.497/0.05 | -0.424/0.101 | | L-Glutathione (reduced) | 0.677/0.004 | 0.656/0.006 | 0.677/0.004 | -0.415/0.110 | 0.426/0.099 | 0.218/0.418 | 0.215/0.425 | -0.285/0.284 |
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Note indicates |rho|ā„0.7, p<0.05, which is considered to be highly correlated and statistically significant. |
