Evaluation of the Biological Effects of Lyophilized Hydrophilic Extract of Rhus coriaria on Myeloperoxidase (MPO) Activity, Wound Healing, and Microbial Infections of Skin Wound Tissues

Table 4

Effect of aqueous extract of Rhus coriaria fruits on non-infected wounds.

Treatment	Parameters of non-infected wounds
	Wound area (cm^2) on day			Scar area (mm^2)	Period of epithelization (Days)
	3	6	9
G1	1.76 ± 0.16	1.56 ± 0.12	1.2 ± 0.09	90.8± 3.4	15.5± 0.5
G2	1.7 ± 0.25	1.5 ± 0.10	0.92 ± 0.07	97.1± 2.5	12.8± 0.65
AERc
G3 (5 mg.mL^−1)	1.4 ± 0.15	0.85 ± 0.06	0.34 ± 0.04	98.5± 1.3	10.8± 0.6
G4 (10 mg.m)	1.1 ± 0.07	0.45 ± 0.04	0.17 ± 0.02	99.8± 1.1	9.5± 0.32

Values represent the mean ± SD, (n=10). Statistical differences were determined by ANOVA followed Student Newman-Keuls test. G1: rats with non infected wounds treated topically with saline solution (200 μL of NaCl, 0.9%); G2: rats with non infected wounds treated with Fibrase® topically at dose of 0.5 g; G3: rats with non infected wounds treated topically with AERc at dose of 5 mg.mL⁻¹; G4: rats with non infected wounds treated topically with AERc at dose of 10 mg.mL-1. P<0.001, P<0.01, as compared to respective saline treatment (G1). P<0.001 as compared to Fibrase-treated animals (G2). AERc: aqueous extract of Rhus Coriaria extract.