Research Article
A Randomized Controlled Trial of Chuanhutongfeng Mixture for the Treatment of Chronic Gouty Arthritis by Regulating miRNAs
Table 3
Baseline information of patients in the 3 groups.
| | Indicators | Control group
(n = 52) | Allopurinol group
(n = 55) | Chuanhutongfeng mixture group (n = 58) | P-value |
| | Age | 49.90 ± 9.00 | 50.50 ± 8.90 | 51.10 ± 9.10 | 0.784 | | Gender (% of males) | 50 (96.15) | 53 (96.36) | 55 (94.83) | 0.908 | | BMI (kg/m2) | 25.33 ± 1.12 | 25.46 ± 1.06 | 25.50 ± 1.26 | 0.726 | | Systolic pressure (mmHg) | 133.00 ± 7.00 | 132.00 ± 8.00 | 134.00 ± 7.00 | 0.354 | | Diastolic pressure (mmHg) | 76.00 ± 5.00 | 75.00 ± 7.00 | 75.00 ± 6.00 | 0.618 | | Disease duration (years) | 9.90 ± 5.11 | 9.91 ± 5.42 | 9.87 ± 5.50 | 0.999 | | Tophus (n, %) | 26 (50.00) | 28 (50.91) | 30 (51.72) | 0.984 | | FBG (mmol/L) | 5.12 ± 0.58 | 5.21 ± 0.46 | 5.17 ± 0.63 | 0.710 | | TC (mmol/L) | 4.89 ±0.45 | 5.03 ± 0.46 | 5.10 ± 0.47 | 0.057 | | TG (mmol/L) | 2.17 ± 0.85 | 2.21 ± 0.72 | 2.16 ± 0.81 | 0.940 | | ALT (U/L) | 30.20 ± 9.50 | 29.50 ± 8.80 | 31.70 ± 8.40 | 0.406 | | AST (U/L) | 25.10 ± 7.70 | 24.80 ± 7.40 | 27.90 ± 8.50 | 0.074 | | eGFR(ml/min/1.73m2) | 110.10 ± 7.40 | 111.50 ± 7.50 | 110.40 ± 7.70 | 0.339 | | SUA (μmol/L) | 532.00 ± 69.00 | 529.00 ± 72.00 | 530.00 ± 74.00 | 0.976 | | ESR (mm/h) | 31.00 ± 14.20 | 33.90 ± 15.70 | 32.20 ± 16.30 | 0.622 | | CRP (mg/L) | 21.30 ± 9.20 | 20.40 ± 10.80 | 22.00 ± 12.10 | 0.734 | | Pain score | 3.54 ± 1.57 | 3.71 ±1.58 | 3.64 ±1.38 | 0.843 | | Swelling score | 1.97 ± 0.89 | 1.97 ± 0.95 | 1.97 ± 0.88 | 1.000 | | Restricted movement score | 1.98 ± 0.72 | 1.98 ± 0.89 | 1.99± 0.88 | 0.997 | | CCL2 (pg/mL) | 538.00 ± 223.00 | 545.00 ± 175.00 | 572.00 ± 160.00 | 0.597 | | CXCL8 (pg/mL) | 619.00 ± 199.00 | 643.00 ± 181.00 | 645.00 ± 218.00 | 0.757 | | miR-486-5p | 2.51 ± 1.22 | 2.31 ± 1.19 | 2.24 ± 1.31 | 0.505 | | miR-339-5p | 4.90 ± 1.98 | 4.93 ± 2.16 | 4.64 ± 2.18 | 0.725 | | miR-361-5p | 3.27 ± 1.80 | 3.15 ± 1.77 | 2.98 ± 1.47 | 0.661 |
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BMI: body mass index; FBG: Fasting blood-glucose; TC: Total cholesterol; TG: triglyceride; ALT: alanine aminotransferase; AST: aspartate aminotransferase; eGFR: estimate glomerular filtration rate; SUA: serum uric acid; ESR: erythrocyte sedimentation rate; CRP: C-reactive protein; CCL2: chemokine (C-C motif) ligand 2; CXCL8: chemokine (C-X-C motif) ligand 8.
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