A Randomized Controlled Trial of Chuanhutongfeng Mixture for the Treatment of Chronic Gouty Arthritis by Regulating miRNAs
Table 5
Comparison of differences in observation indicators after 4 and 8 weeks treatment in the 3 groups.
Indicators
Control group (n = 52)
Allopurinol group (n = 55)
Chuanhutongfeng mixture group (n = 58)
4 weeks
8 weeks
4 weeks
8 weeks
4 weeks
8 weeks
∆ESR (mm/h)
-8.00 ± 3.80
-9.00 ± 3.60
-16.20 ± 9.30
-17.30 ± 9.20
-16.40 ± 4.30
-19.00 ± 4.60
∆CRP (mg/L)
-1.20 ± 0. 50
-2.50 ± 0.50
-11.80 ± 7.80
-12.00 ±7.70
-15.40 ± 8.90
-15.50 ± 8.90
∆Pain score
-1.44 ± 0.51
-1.55 ± 0.50
-2.32 ± 0.60
-2.41 ± 0.53
-2.36 ± 0.53
-2.56 ± 0.46
∆Swelling score
-1.11 ± 0.42
-1.15 ± 0.42
-1.46 ± 0.51
-1.47 ± 0.41
-1.47 ± 0.47
-1.51 ± 0.47
∆Restricted movement score
-1.00 ± 0.49
-1.03 ± 0.49
-1.47 ± 0.48
-1.48 ± 0.48
-1.49 ± 0.50
-1.53 ± 0.46
∆SUA (μmol/L)
-14.00 ± 12.00
-26.00 ± 23.00
-64.00 ± 21.00
-70.00 ± 21.00
-90.00 ± 47.00
-170.00 ± 49.00
∆eGFR (ml/min/1.73 m2)
0.40 ± 2.10
0.40 ± 2.90
-3.00 ± 2.70
-3.90 ± 3.60
3.20 ± 1.70
5.70 ± 2.60
∆FPG (mmol/L)
-0.05± 0.22
-0.10 ± 0.22
-0.10 ± 0.25
-0.10 ± 0.25
-0.22 ± 0.32
-0.20 ± 0.32
∆TG (mmol/L)
-0.56 ± 0.37
-0.58 ± 0.37
-0.63 ± 0.36
-0.68 ± 0.35
-0.61 ± 0.31
-0.65 ± 0.31
∆TC (mmol/L)
-0.22 ± 0.23
-0.18 ± 0.23
-0.31 ± 0.22
-0.36 ± 0.22
-0.43 ± 0.19
-0.49± 0.19
∆CCL2 (pg/mL)
-21.00 ± 24.00
-32.00 ± 24.00
-88.00 ± 76.00
-163.00 ± 136.00
-97.00 ± 89.00
-174.00 ± 129.00
∆CXCL8 (pg/mL)
-14.00 ± 18.00
-21.00 ± 18.00
-22.00 ± 28.00
-43.00 ± 38.00
-93.00 ± 93.00
-212.00 ± 133.00
∆miR-486-5p
0.12 ± 0.12
0.15 ± 0.16
0.58 ± 0.53
3.28 ± 0.55
0.78 ± 0.67
5.78 ± 1.72
∆miR-339-5p
0.08 ± 0.16
0.11 ± 0.19
0.09 ± 0.14
1.69 ± 0.47
0.60 ± 0.49
4.25 ± 1.61
∆miR-361-5p
0.13 ± 0.10
0.28± 0.15
0.25 ± 0.15
4.43 ± 1.06
0.63 ± 0.20
6.53 ± 2.79
Note. ESR: erythrocyte sedimentation rate; CRP: C-reactive protein; eGFR: estimate glomerular filtration rate; FBG: fasting blood-glucose; TG: triglyceride; TC: total cholesterol; SUA: serum uric acid; CCL2: chemokine (C-C motif) ligand 2; CXCL8: chemokine (C-X-C motif) ligand 8. ∆ values: the value of index which were measured before or after treatment subtracted their baseline value; compared with the control group after 4 weeks P < 0.05, 8 weeks, P < 0.05; compared with the allopurinol group after 4 weeks, P< 0.05, 8 weeks, P< 0.05.
