Dracohodin Perochlorate Stimulates Fibroblast Proliferation via EGFR Activation and Downstream ERK/CREB and PI3K/Akt/mTOR Pathways In Vitro

Figure 7

In the DP-treated cells, DP preferentially recognized and activated EGFR receptors on the cell surface. Phosphorylated EGFR stimulated downstream ERK and PI3K signaling pathway activation, which triggered their downstream protein activation. Finally, the cell proliferation was accelerated.