Detarium microcarpum, Guiera senegalensis, and Cassia siamea Induce Apoptosis and Cell Cycle Arrest and Inhibit Metastasis on MCF7 Breast Cancer Cells

Figure 4

Population of MCF7 cells at different stages of the cell cycle before and after treatment with plant extracts. The effect of the plant extracts on apoptosis of MCF7 cells was determined by flow cytometry analysis using Annexin V/PI stain. Detarium microcarpum methanol extract (DMME), Cassia siamea methanol extract (CSME), Guiera senegalensis methanol extract (GSME), Detarium microcarpum aqueous extract (DMAE), and Guiera senegalensis aqueous extract (GSAE). Values that are marked with () are significantly different from the control (cell cycle distribution of the untreated cells) at p < 0.01.