Evaluation of Antimalarial Activity of the Leaf Latex and TLC Isolates from Aloe megalacantha Baker in Plasmodium berghei Infected Mice

Table 1

Percentage suppression and mean survival time of Plasmodium berghei infected mice after treatment with leaf latex and TLC isolates obtained from A. megalacantha.

Test substance	Dose (mg/kg/day)	%Parasitemia ± SEM	%Suppression	MST (days)
NC	10 ml/kg	47.0 ± 3.49	0.00	6.4 ± 0.25
Latex	100	32.7 ± 1.21	30.4	7.2 ± 0.37
	200	26.6 ± 2.99	43.4	9.0 ± 0.51
	400	20.5 ± 1.22	56.4	10.1 ± 0.51
AM1	100	31.8 ± 5.05	32.3	7.6 ± 0.6
	200	22.9 ± 3.73	51.3	8.8 ± 0.58
	400	15.3 ± 3.78	67.4	10.0 ± 0.84
AM2	100	28.3 ± 5.90	39.8	7.8 ± 0.49
	200	23.2 ± 3.90	50.6	8.8 ± 0.37
	400	16.8 ± 4.19	64.2	9.6 ± 0.68
AM3	100	22.3 ± 4.77	52.6	8.2 ± 0.58
	200	14.4 ± 2.38	69.4	9.6 ± 0.55
	400	9.6 ± 1.75	79.6	10.4 ± 0.51
CQ	25	0.00	100	ND

Values are presented M ± SEM; n =5; mean value is significant (P<0.05) and mean value highly significant (P<0.001) when compared with negative control (NC) group; ND = no death within the follow-up period; MST= mean survival time in days.