Salvia miltiorrhiza and Carthamus tinctorius Extract Prevents Cardiac Fibrosis and Dysfunction after Myocardial Infarction by Epigenetically Inhibiting Smad3 Expression

Figure 2

SCE suppresses MI-induced inflammatory responses in heart tissue. RT-qPCR analysis of Il1b, Il6, Tnf, and Il10 mRNA in heart tissues from sham group, remote area (RA), or infarct border area (BA) from mice with SCE administration (SCE) or control mice (Ctrl) (n = 3 mice per group) at the indicated days after MI. Expression levels were shown as relative fold values compared with the sham group (calculated as 1 for each gene at the indicated days) after normalization to GAPDH. Data are from three independent experiments (mean ± SEM). P < 0.01, ANOVA with LSD t-test.