Metabolic Response in Rats following Electroacupuncture or Moxibustion Stimulation

Figure 4

Enhanced volcano plots for screening of candidate metabolites associated with stimulation of the SM acupoints, showing data from cortex (top row), stomach (middle), and liver (bottom) tissues. VIP value and are represented by circles size and colour, respectively. For each comparison, VIP values are categorized into four segments: top 5%, top 10%, top 20%. and the rest 80% with each represented by a circle of decreasing size. A cut-off dotted line that represents p-value = 0.05 (i.e., -lg(p-value)=1.30) is included in each plot, and differential metabolites with p < 0.05 will have value of -lg(p-value) > 1.30. Abbreviations: adenosine monophosphate (AMP), adenosine (Ado), adenosine triphosphate (ATP), acetate (Ace), alanine (Ala), aspartate (Asp), betaine (Bet), creatine (Cr), ethanolamine (EthA), formate (For), guanidinoacetate (GA), gamma-aminobutyrate (GABA), guanosine (Gu), glutamine (Gln), glutamate (Glu), hypoxanthine (HX), inosine (Ino), isoleucine (Ile), leucine (Leu), lactate (Lac), oxaloacetate (OA), phosphocholine (PC), phenylalanine (Phe), serine (Ser), taurine (Tau), tyrosine (Tyr), uridine (Ud), valine (Val), and xanthine (Xan).