Effects of 12-Week Supplementation of a Polyherbal Formulation in Old Adults with Prehypertension/Hypertension: A Randomized, Double-Blind, Placebo-Controlled Trial
Table 4
Changes in individual and combined severity scores of anti-hypertension medicine treatment-related symptoms (mean ± s.d) after 12 weeks of HyperBalance/placebo intervention.
Group
Before intervention
After intervention
Difference between before and after intervention
t / P value
Dizziness
HyperBalance
2.32 ± 0.55
0.82±0.44
1.50±0.54
19.498/<0.001
Placebo
2.42 ± 0.50
2.02±0.64
0.40±0.57
4.779/<0.001
t / P value
0.91/ 0.37
10.94/ <0.001
9.778/<0.001++
Headache
HyperBalance
2.22 ± 0.62
0.46±0.503
1.76±0.48
26.124/<0.001
Placebo
2.31 ± 0.59
1.81±0.607
0.50±0.58
5.937/<0.001
t / P value
0.76/ 0.45
12.03/ <0.001++
11.683/<0.001++
Ringing/buzzing in ears
HyperBalance
1.02 ± 0.32
0.44±0.501
0.58±0.54
7.624/<0.001
Placebo
1.08 ± 0.28
1.04±0.29
0.04±0.20
1.430/0.159
t / P value
1.04/ 0.30
7.24, <0.01
6.608/<0.001++
Rapid heart rate and chest tightness
HyperBalance
0.96 ± 0.20
0.30±0.46
0.66±0.48
9.753/<0.001
Placebo
0.98 ± 0.14
0.92±0.28
0.06±0.24
1.770/0.083
t / P value
0.55, 0.59
7.94, <0.001
7.828/<0.001++
Combined symptom scores
HyperBalance
6.52±1.27
2.02±1.46
4.50±1.36
23.414/ <0.001
Placebo
6.79±1.07
5.79±1.41
1.00±1.29
5.378/ <0.001
t / P value
1.145/0.255
12.967/<0.001
13.074/<0.001++
, P<0.05, comparison of baseline with the post-intervention values within each treatment group; ++, P<0.001, comparison of the difference between Hyperbalance and placebo groups after the 12-week intervention.
