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Evidence-Based Complementary and Alternative Medicine
Volume 2019, Article ID 7095684, 14 pages
https://doi.org/10.1155/2019/7095684
Research Article

Alcohol Induces More Severe Fatty Liver Disease by Influencing Cholesterol Metabolism

1Zhejiang University of Technology, Hangzhou, Zhejiang 310014, China
2Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310053, China
3Wenzhou Medical University, Wenzhou, Zhejiang 325035, China

Correspondence should be addressed to Gui-Yuan Lv; moc.361@yglmctjz and Su-Hong Chen; nc.ude.tujz@gnohusnehc

Received 11 October 2018; Accepted 13 January 2019; Published 12 February 2019

Academic Editor: Yoshiji Ohta

Copyright © 2019 Bo Li et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Objectives. Fatty liver disease (FLD) is a major cause of morbidity and mortality worldwide. Dietary cholesterol and alcohol consumption are important risk factors for the progression of FLD, but whether and how alcohol induces more severe FLD with cholesterol ingestion remain unclear. Herein, we mainly used the Lieber-DeCarli diet to establish the FLD mouse model to investigate the synergistic effects of alcohol and cholesterol metabolism on liver damage. The indices of aspartate transaminase (AST), alanine transaminase (ALT), low-density lipoprotein cholesterol (LDL-c), and total cholesterol (TC) levels, inflammation foci, and pathogenesis by hematoxylin and eosin (H&E) and Oil Red O staining revealed that alcohol induces more severe liver damage by influencing cholesterol metabolism, which might be primarily related to the influence of cholesterol absorption, synthesis, and excretion on the liver or small intestine. Moreover, inhibition of absorption of intestinal cholesterol, but not of fat, sucrose, and alcohol, absorption into the body’s metabolism by Ezetimibe, significantly improved FLD in rats fed with the high fat-cholesterol-sucrose and alcohol diet. These results showed that alcohol plays an important role in cholesterol metabolism in FLD.