Effect of Short-Course Oral Ciprofloxacin on Isoflavone Pharmacokinetics following Soy Milk Ingestion in Healthy Postmenopausal Women

Table 6

Pharmacokinetic parameters of genistein obtained from 11 subjects receiving a single oral administration of soy milk (SOY Phase) and a short-course oral ciprofloxacin followed by a single oral administration of soy milk (CIPRO/SOY phase).

Pharmacokinetic parameters	Genistein
	SOY phase		CIPRO/SOY phase
	Mean±SD	Median (IQR)	Mean±SD	Median (IQR)
(ng/mL)	826.64±462.97	731.95 (521.01)	434.75±276.2	306.17 (214.37
(h)	6.00±1.55	6.00 (0.00)	3.27±2.2	2.00 (2.00
(ng.h/mL)	9583.48±6482.03	8911.53 (7711.23)	4956.98±4263.7	3834.93 (4106.07
(ng.h/mL)	10540.60±7024.65	9284.07 (7789.07)	5791.53±4567.8	4366.76 (3976.55
t1/2 (h)	7.40±1.20	7.26 (1.57)	7.54±1.69	7.16 (1.69)

Data represent mean±SD and median (interquartile range, IQR). <0.05 versus SOY phase using a paired t-test. <0.05 versus SOY phase using Wilcoxon’s signed-rank test.