Safflower Yellow B Protects Brain against Cerebral Ischemia Reperfusion Injury through AMPK/NF-kB Pathway
Neuroprotective effect of SYB on I/R-induced brain injuries. Animals were given SYB (2, 4, and 8 mg/kg) by intraperitoneal injection before reperfusion for 20 h (a). The postural reflex test results (b). The beam balance test results (c). Adhesive removal test results (d). The neurological deficit score of rats was evaluated according to Longa’s method (e). Infarction area was measured by TTC staining (f). Brain water content was measured as MOTHED shown. After reperfusion, the blood was collected and the levels of LDH (g), NSE (h), and S-100β (i) were measured by relative kits as the protocol directed. Data were presented as mean ± SD. ##P<0.01 versus sham group; .05; .01 versus sham group.