Research Article

Spinal Cord Glycine Transporter 2 Mediates Bilateral ST35 Acupoints Sensitization in Rats with Knee Osteoarthritis

Figure 1

Left KOA induces bilateral ST35, but not GB37 or nonacupoint control area sensitization. (a) Schematic diagram for the time frame of the experiment. (b) The locations of ST35, GB37, and the nonacupoint area. (c-e) Paw withdrawal mechanical threshold at ST35, GB37, and the nonacupoint area. Two-way repeated measures ANOVA followed by Bonferroni’s post hoc test was used, P < 0.01, and P < 0.001 versus Control-L group; #P < 0.05, ##P < 0.01, and ###P < 0.001 versus Control-R group; n = 8 per group. ((f) and (g)) The total number of mast cells and the percentages of degranulated mast cells in all groups. One-way ANOVA test followed by Tukey’s post hoc test was used, P < 0.01, and P < 0.001 versus Control-L group; #P < 0.05, ##P < 0.01 versus Control-R group; n = 6 per group. All data are shown as the mean ± SEM.
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