Research Article

Spinal Cord Glycine Transporter 2 Mediates Bilateral ST35 Acupoints Sensitization in Rats with Knee Osteoarthritis

Figure 3

Left KOA induces c-Fos upregulation in bilateral dorsal horns of spianal cord. (a) Representative fluorescent staining image of c-Fos expression at L3-5 dorsal horn (red fluorescence) in control or MIA rats at 14 days after saline or MIA injection. (b) c-Fos-positive cell counts in L3-5, laminae I-III. Scale bar is 100 μm; P < 0.01 versus Control-L group; ##P < 0.01 versus Control-R group; n = 8 per group. ((c) and (d)) Western blot analysis for the expression of c-Fos in bilateral L3-L5 spinal cord dorsal horn at 14 days after MIA or saline injection. P < 0.05 versus Control-L group; #P < 0.05 versus Control-R group; n = 6 per group. One-way ANOVA followed by Tukey’s post hoc test was used. All data are presented as the mean ± SEM.
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