Antibacterial and Antibiotic Modifying Potential of Crude Extracts, Fractions, and Compounds from Acacia polyacantha Willd. against MDR Gram-Negative Bacteria

Table 1

Minimal inhibitory concentration (MIC) and minimal bactericidal concentration (MBC) in μg/mL of crude leaf and bark extracts, isolated compounds and chloramphenicol against reference strains and MDR Gram-negative bacteria.

Bacterial strains	Tested samples, MIC and MBC (in bracket) values (µg/mL)
	Leaf extract (APL)	Bark extract (APB)	Chloramphenicol
Escherichia coli
ATCC8739	1024 (-)	512 (-)	2 (64)
AG102	512 (-)	-	32 (256)
AG100Atet	512 (-)	-	32 (256)
ATCC10536	1024 (-)	-	2 (32)
Enterobacter aerogenes
ATCC13048	256 (-)	8 (-)	16 (128)
CM64	-	-	256 (-)
EA27	1024 (-)	256 (-)	32 (256)
EA289	-	-	32 (256)
Klebsiella pneumoniae
ATCC11296	1024 (-)	-	32 (256)
KP55	-	128 (-)	64 (256)
KP63	-	-	32 (256)
Pseudomonas aeruginosa
PA01	64 (-)	256 (-)	64 (-)
PA124	256 (-)	512 (-)	256 (-)
Providencia stuartii
NEA16	1024 (-)	-	64 (256)
ATCC29916	8 (-)	256 (-)	64 (256)

(-): MIC or MBC value > 1024 µg/mL for APL and APB or >256 for chloramphenicol; MIC values in bold: significant antibacterial effect [18].