Research Article

Cytostatic and Antiproliferative Activities of F5 Fraction of Crinum amabile Leaf Chloroform Extract Showed Its Potential as Cancer Chemotherapeutic Agent

Table 2

values of different extracts and different fractions of leaves Crinum amabile, against various cancer cell lines, using MTS assay. All extract and fraction were exposed for 48 hours with the highest concentration tested being 200 μg/mL. All results were presented as mean ± SEM, of three individual experiments. Triplicate samples were tested in each individual experiment (n = 9).

Samples, (μg/mL)
BreastColonLeukemia
MCF-7MDA-MB-231HCT-116HT-29REH

PE> 200> 200> 200> 200> 200
CE116.66±7.99169.92±6.12158.69±8.48126.39±3.96> 200
ME> 200> 200> 200> 200> 200
WE> 200> 200> 200> 200> 200

F1 Fraction> 200> 20060.21±0.88> 200>200
F2 Fraction> 200147.52±2.41> 200> 200117.64±1.50
F3 Fraction> 200120.59±1.2038.49±1.17> 200> 200
F4 Fraction> 20084.62±3.5171.08±2.96> 20089.88±0.58
F5 Fraction25.61±3.1527.15±1.2140.14±2.5339.53±1.6552.69±8.10
F6 Fraction122.03±5.21159.93±5.81> 200> 200> 200

5-FU2.18±0.20185.58±6.142.33±0.07-3.63±0.10