Herbal Formula Fo Shou San Attenuates Alzheimer’s Disease-Related Pathologies via the Gut-Liver-Brain Axis in APP/PS1 Mouse Model of Alzheimer’s Disease
Figure 2
FSS attenuates neuronal damage in the hippocampus of APP/PS1 AD mice. The hippocampal CA1 regions of mice were observed using hematoxylin-eosin staining: at 100× (a–f) and 400× (g–l) magnification. (a, g) The WT group exhibited normal neuron structure, number, and nerve fibers. (b, h) The AD group exhibited loss of neurons, shrunken darkly stained cells, no peripheral staining, and severe distortion of neuron fibers. (c, i) The CA1 regions of the donepezil-treated group appeared to be very similar to those of the WT group. (d, j) and (e, k) The FSS-H group and FSS-M group both showed some cellular damage compared with the WT group. (f, l) The CA1 regions of the FSS-L group showed more damage, but less than that observed in the AD group. FSS: Fo Shou San; AD: Alzheimer’s disease; WT: wild type; FSS-L: 1.6 g/kg/day; FSS-M: 3.2 g/kg/day; FSS-H: 6.4 g/kg/day.