Effects of Xuesaitong on the Pharmacokinetics of Losartan: An In Vivo UPLC-MS/MS Study

Table 4

Pharmacokinetic parameters of losartan and EXP3174 in rats following oral administration of two pretreatments (A: losartan alone; B: losartan plus Xuesaitong).

Parameter	Losartan		EXP3174
	Losartan alone (A)	Losartan plus Xuesaitong (B)	Losartan alone (A)	Losartan plus Xuesaitong (B)
t1/2 (h)	6.35 ± 2.10	4.26 ± 1.51	8.22 ± 1.41	6.29 ± 1.38
Tmax (h)	0.13 ± 0.05	1.06 ± 1.04	6.83 ± 4.12	11.33 ± 1.63
Cmax (μg·mL^−1)	1.60 ± 0.59	1.50 ± 0.49	1.61 ± 0.61	1.60 ± 0.54
AUC0–t (μg·mL^−1·h)	12.92 ± 5.01	14.17 ± 4.21	27.02 ± 10.49	26.40 ± 10.08
AUC0–inf (μg·mL^−1·h)	13.54 ± 5.54	14.28 ± 4.23	29.40 ± 11.85	27.64 ± 10.88
AUMC0–t (μg·mL^−1·h^2)	101.66 ± 26.75	120.88 ± 27.41	324.38 ± 65.68	320.31 ± 58.17
AUMC0–inf (μg·mL^−1·h^2)	101.15 ± 26.13	127.30 ± 25.52	440.49 ± 34.34	361.21 ± 36.31
MRT0–t (h)	8.41 ± 1.80	7.76 ± 0.88	12.42 ± 1.48	11.98 ± 1.27
MRT0–inf (h)	9.86 ± 2.80	8.03 ± 1.00	15.09 ± 2.72	13.31 ± 2.08
Vd (mL)	7.20 ± 2.41	4.41 ± 1.61	4.52 ± 1.66	3.62 ± 1.21
CL (mL·h^−1)	0.84 ± 0.32	0.77 ± 0.31	0.39 ± 0.16	0.42 ± 0.21

(losartan plus Xuesaitong vs. losartan alone).