Acute and Subchronic Oral Toxicity of Fermented Green Tea with Aquilariae Lignum in Rodents

Table 1

Postmortem abnormalities after a single oral dose of fGT.

	Control (male, female)	fGT (male, female)
		2.0 g/kg	1.0 g/kg	0.5 g/kg
LN: hypertrophy +1	1/10 (1/5, 0/5)	1/10 (1/5, 0/5)	2/10 (1/5, 1/5)	1/10 (1/5, 0/5)
Spleen: atrophy +1	2/10 (1/5, 1/5)	1/10 (1/5, 0/5)	1/10 (0/5, 1/5)	2/10 (1/5, 1/5)
Thymus: atrophy +1	2/10 (1/5, 1/5)	0/10 (0/5, 0/5)	0/10 (0/5, 0/5)	2/10 (1/5, 1/5)
Lung: congestion +1	3/10 (2/5, 1/5)	2/10 (1/5, 1/5)	2/10 (1/5, 1/5)	2/10 (1/5, 1/5)
Uterus
Edema +1	1/5 (—, 1/5)	1/5 (—, 1/5)	0/5 (—, 0/5)	3/5 (—, 3/5)
Edema +2	1/5 (—, 1/5)	1/5 (—, 1/5)	1/5 (—, 1/5)	0/5 (—, 0/5)

Mice (n = 5 per group each) were orally administered distilled water as a vehicle control (Control) or aqueous extracts of fermented green tea with Aquilariae Lignum (fGT). Abnormal changes are scored as +1 and +2 for slight and moderate changes, respectively. Mice showing the abnormalities are listed as a number per total number. LN = lymph node.