Acute and Subchronic Oral Toxicity of Fermented Green Tea with Aquilariae Lignum in Rodents

Table 3

Histopathological abnormalities after a single oral dose of fGT.

	Control (male, female)	fGT (male, female)
		2.0 g/kg	1.0 g/kg	0.5 g/kg
LN: LC hyperplasia +1	1/10 (1/5, 0/5)	1/10 (1/5, 0/5)	2/10 (1/5, 1/5)	1/10 (1/5, 0/5)
Spleen: LC decrease +1	3/10 (1/5, 2/5)	1/10 (1/5, 0/5)	1/10 (0/5, 1/5)	2/10 (1/5, 1/5)
Liver: IF infiltration +1	0/10 (0/5, 0/5)	0/10 (0/5, 0/5)	1/10 (0/5, 1/5)	0/10 (0/5, 0/5)
Lung: congestion +1	3/10 (2/5, 1/5)	2/10 (1/5, 1/5)	2/10 (1/5, 1/5)	2/10 (1/5, 1/5)

Mice (n = 5 per group each) were orally administered distilled water (Control) or fGT. The score +1 means slight abnormal changes. Mice showing the abnormalities are listed as a number per total number. LN = lymph node; LC = lymphoid cell; IF = inflammatory cell.