Acute and Subchronic Oral Toxicity of Fermented Green Tea with Aquilariae Lignum in Rodents
Table 4
Hematological changes after a repeated oral dose of fGT for 13 weeks.
Control (male, female)
fGT (male, female)
2.0 g/kg
1.0 g/kg
0.5 g/kg
Erythrocyte (M/μL)
7.63 ± 0.23/6.86 ± 0.58
7.95 ± 0.62/6.58 ± 0.44
7.66 ± 0.57/6.92 ± 0.79
7.72 ± 0.29/6.75 ± 0.92
Hematocrit (%)
64.94 ± 2.23/62.32 ± 3.81
67.28 ± 1.89/59.82 ± 2.91
62.34 ± 4.55/62.38 ± 5.19
64.32 ± 1.58/62.52 ± 7.04
Hemoglobin (g/dL)
13.90 ± 0.50/13.78 ± 0.49
14.35 ± 0.26/13.38 ± 0.70
13.62 ± 1.02/13.34 ± 1.07
14.04 ± 0.55/13.30 ± 1.41
MCV (fL)
85.12 ± 1.30/90.96 ± 3.58
82.38 ± 2.94/91.00 ± 3.12
81.42 ± 2.05/90.42 ± 2.89
83.40 ± 1.36/92.82 ± 2.83
MCH (pg)
18.22 ± 0.28/20.20 ± 1.66
17.58 ± 0.74/19.76 ± 0.90
17.78 ± 0.38/19.34 ± 0.76
18.20 ± 0.45/19.76 ± 0.81
MCHC (g/dL)
21.62 ± 0.44/22.18 ± 1.71
21.33 ± 0.46/21.70 ± 0.41
21.84 ± 0.26/21.40 ± 0.25
21.84 ± 0.42/21.32 ± 0.25
Leukocytes (K/μL)
8.75 ± 1.80/5.84 ± 2.26
8.42 ± 1.99/7.27 ± 2.84
9.45 ± 1.93/5.69 ± 1.16
7.43 ± 0.67/5.61 ± 2.32
Neutrophils (%)
15.34 ± 1.71/14.08 ± 3.45
18.10 ± 7.41/17.82 ± 2.99
18.10 ± 5.06/17.60 ± 4.43
18.58 ± 7.75/15.46 ± 12.23
Eosinophils (%)
1.91 ± 0.96/2.27 ± 0.46
0.93 ± 0.27/1.94 ± 0.59
1.95 ± 0.64/2.33 ± 0.49
1.88 ± 0.63/1.78 ± 0.81
Basophils (%)
3.01 ± 0.27/3.37 ± 0.90
3.16 ± 0.35/2.85 ± 0.41
2.85 ± 0.62/3.03 ± 1.33
2.17 ± 0.12/3.18 ± 1.18
Lymphocytes (%)
78.84 ± 2.21/79.40 ± 2.94
77.25 ± 7.74/77.02 ± 2.30
76.24 ± 4.74/75.86 ± 5.31
76.92 ± 7.93/78.38 ± 11.78
Monocytes (%)
0.95 ± 0.66/0.89 ± 0.54
0.60 ± 0.21/0.36 ± 0.34
0.86 ± 0.43/1.19 ± 1.50
0.45 ± 0.31/1.22 ± 1.02
Platelets (K/nL)
0.84 ± 0.18/0.74 ± 0.17
0.98 ± 0.08/0.86 ± 0.12
0.99 ± 0.10/0.86 ± 0.15
0.97 ± 0.14/0.59 ± 0.27
Rats (n = 5 per group each) were orally administered distilled water (Control) or fGT. The hematological items are expressed as mean ± SD. versus the control group by the Scheffe test. MCV = mean corpuscular volume; MCH = MC hemoglobin; MCHC = MCH concentration.
