Ethnopharmacology Study of Plants from Atlantic Forest with Leishmanicidal Activity

Table 1

Leishmanicidal activity of EtOH and n-hexane extracts were assayed against promastigote and amastigote forms of L. (L.) amazonensis. Cytotoxicity was analyzed using J774 macrophage cell lineage. EC₅₀ = effective contraction 50%; CC₅₀ = cytotoxic concentration 50%; SIp = selectivity index towards promastigote forms; SIa = selectivity index towards amastigote forms.

Species (Family)	Part indicated	Extract	EC50 (g/mL); promastigote	CC50 (g/mL); macrophage	EC50 (g/mL); amastigote	SIp	SIa
A. brasiliana (Amaranthaceae)	Leaves	EtOH	N/A	≥ 100.0	N/A	-	-
		n-hexane	N/A	≥ 100.0	N/A	-	-
E. uniflora (Myrtaceae)	Leaves	EtOH	47.0 ± 8.5	≥ 100.0	22.1 ± 5.8	≥ 2.1	≥4.5
		n-hexane	14.0 ± 3.3	50.5 ± 7.2	9.2 ± 1.2	3.6	5.5
J. gossypiifolia (Euphorbiaceae)	Leaves	EtOH	N/A	≥ 100.0	N/A	-	-
		n-hexane	N/A	≥ 100.0	N/A	-	-
S. terebinthifolia (Anacardiaceae)	Fruits	EtOH	64.6 ± 10.2	91.4 ± 4.0	30.6 ± 9.6	1.4	2.9
		n-hexane	13.9 ± 4.3	52.0 ± 2.4	43.1 ± 10.3	3.7	1.2
S. terebinthifolia (Anacardiaceae)	Leaves	EtOH	30.5 ± 6.3	92.2 ± 8.0	32.6 ± 5.1	3.0	2.8
		n-hexane	14.7 ± 3.0	38.1 ± 7.3	17.4 ± 1.0	2.6	2.2
Miltefosine	-	-	2.8 ± 0.5	41.3 ± 4.6	6.8 ± 2.1	14.8	6.1