Effect of Tripterygium wilfordii Polycoride on the NOXs-ROS-NLRP3 Inflammasome Signaling Pathway in Mice with Ulcerative Colitis
ROS generation in the mouse colon tissues and neutrophils of different groups. Bars of the two colors, respectively, indicate the ROS generation in the mouse colon tissues and neutrophils. Mice in the model control group, low TWP, middle TWP, and high TWP groups were provided a 5% DSS solution for one week. Meanwhile, the low TWP, middle TWP, and high TWP groups received different doses of TWP for 2 weeks. At the end of the experiment, the mouse colon tissues and neutrophils of each group were taken for the ROS content detection via the DCFH-DA (10 mM) fluorescence method. The results showed that the ROS in the colon tissues and neutrophils of the different TWP groups was significantly lower than that of the model control group and higher than that of the normal control group. ROS content decreases with the increased dose of TWP, and the differences among the TWP groups were significant. Each bar represents mean ± SD (n = 9); vs. model; † vs. low TWP; ▶ vs. middle TWP.
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