Toxicity Assessment of Chinese Herbal Medicine Cynomorium songaricum Rupr
Table 2
The results of the bacterial reverse mutation test.
Chemical
Dose (μg/plate)
Revertant colonies/plate
S9
TA97
TA98
TAl00
TAl02
TA1535
Suo Yang
8
-
113 ± 9
37 ± 8
172 ± 21
286 ± 10
16 ± 2
40
-
120 ± 13
40 ± 1
172 ± 19
289 ± 13
10 ± 4
200
-
119 ± 15
46 ± 4
136 ± 12
262 ± 10
10 ± 8
1000
-
125 ± 17
46 ± 2
134 ± 5
276 ± 7
13 ± 4
5000
-
121 ± 15
39 ± 6
151 ± 29
256 ± 5
8 ± 3
Untreated control
0
-
118 ± 14
37 ± 7
135 ± 18
275 ± 19
10 ± 3
Solvent control 1
0
-
111 ± 5
38 ± 8
151 ± 14
292 ± 3
11 ± 6
Solvent control 2
0
-
121 ± 10
41 ± 4
143 ± 15
288 ± 14
11 ± 5
Positive control 1
50
-
1723 ± 35
818 ± 67
786 ± 56
Positive control 2
1.5
-
1016 ± 90
462 ± 23
Suo Yang
8
+
121 ± 7
40 ± 1
167 ± 25
277 ± 22
15 ± 3
40
+
114 ± 11
37 ± 10
151 ± 35
272 ± 10
9 ± 4
200
+
127 ± 14
41 ± 5
158 ± 34
273 ± 21
16 ± 2
1000
+
123 ± 12
39 ± 7
165 ± 34
263 ± 19
13 ± 5
5000
+
120 ± 8
33 ± 4
154 ± 27
277 ± 23
13 ± 7
Negative control
0
+
126 ± 5
38 ± 10
150 ± 13
262 ± 13
13 ± 3
Solvent control 1
0
+
124 ± 19
36 ± 6
177 ± 5
279 ± 14
11 ± 6
Solvent control 2
0
+
122 ± 6
37 ± 6
148 ± 14
287 ± 7
11 ± 6
Positive control 3
10
+
1533 ± 90
2141 ± 207
921 ± 47
Positive control 4
50
+
796 ± 84
Positive control 5
200
+
518 ± 19
Values are expressed as the means ± SD (n = 10). Solvent control 1: sterile water; Solvent control 2: DMSO; Positive control 1: dimethylaminobenzene diazosulfonate sodium; Positive control 2: sodium azide; Positive control 3: 2-aminoanthracene; Positive control 4: 1,8-dihydroxyanthraquinone; Positive control 5: Endoxan. P< 0.01 statistically significant compared to the untreated control group.