Assessment of the In Vitro Antischistosomal Activities of the Extracts and Compounds from Solidago Microglossa DC (Asteraceae) and Aristolochia Cymbifera Mart. & Zucc. (Aristolochiaceae)

Table 1

In vitro schistosomicidal and cytotoxic activities of Sm and Ac.

Groups	Dead worms (%)^a,c	Motor activity reduction (%)^a		Worms with tegumental alterations (%)^a		Cytotoxicity CC50 (μg/mL)^d
		Slight	Significant	Partial	Extensive
Control^b	—	—	—	—	—	—
PZQ (2 μM)	100	—	100	—	100	—
DMSO 0.5%	—	—	—	—	—	—
Sm^c						>200
200	100	—	100	—	100
100	50	—	100	—	100
50	—	50	50	50	50
25	—	50	50	50	50
10	—	—	—	—	—
Ac^c						>200
200	100	—	100	—	100
100	100	—	100	—	100
50	50	50	50	50	50
25	25	50	50	50	50
10	—	25	—

^aPercentages relative to the 20 worms investigated. ^bRPMI 1640. ^cIncubation period: 24 h with concentrations in μg/m. ^dCC₅₀ values (50% cytotoxicity concentration) on Vero cells.