Assessment of the In Vitro Antischistosomal Activities of the Extracts and Compounds from Solidago Microglossa DC (Asteraceae) and Aristolochia Cymbifera Mart. & Zucc. (Aristolochiaceae)

Table 2

In vitro schistosomicidal and cytotoxic activities of isolated compounds from Sm and Ac.

Groups	Dead worms (%)^a,	Motor activity reduction (%)^a		Worms with tegumental alterations (%)^a		Cytotoxicity CC50 (μM)^d
		Slight	Significant	Partial	Extensive
Control^b	—	—	—	—	—	—
PZQ^c 2 μM	100	—	100	25	75	—
DMSO 0.5%	—	—	—	—	—	—
		Compounds^c
α-Amirin (1)						>100
100	—	—	100	—	—
50	—	50	50	—	—
25	—	—	—	—	—
Baurenol (2)						>100
100	—	—	100	—	—
50	—	50	50	—	—
25	—	—	—	—	—
Spinasterol (3)						>100
100	—	100	—	—	—
50	—	—	—	—	—
25	—	—	—	—	—
Populifolic acid (4)						>100
100	—	—	100	—	—
50	—	—	—	—	—
25	—	—	—	—	—
Cubebin (5)						>100
100	—	—	100	—	—
50	—	50	50	—	—
25	—	50	50	—	—
2-oxopopulifolic acid methyl ester (6)						>100
100	100	—	100	100	—
50	50	—	100	—	—
25	—	50	—	—	—
2-oxopopulifolic acid (7)						>100
100	100	—	100	100	—
50	50	—	100	—	—
25	—	50	—	—	—

^aPercentages relative to the 20 worms investigated. ^bRPMI 1640. ^cIncubation period: 24 h, tested at μM. ^dCC₅₀ values CC₅₀ values (50% cytotoxic concentration) on Vero cells.