Herb-Drug Interaction: Application of a UPLC-MS/MS Method to Determine the Effect of Polygonum capitatum Extract on the Tissue Distribution and Excretion of Levofloxacin in Rats

Table 2

Calibration curves, linear ranges, correlation coefficients, and LLOQ of LVFX in rat tissues and urine and fecal samples.

Biosamples	Calibration curves	R^2	Linear ranges (ng/mL)	LLOQ (ng/mL)
Heart	y = 0.1582x + 2.651	0.9966	5.01–15,030.00	5.01
Liver	y = 0.1127x + 4.3228	0.9951	5.01–15,030.00	5.01
Spleen	y = 0.1837x + 3.1029	0.9967	5.01–15,030.00	5.01
Lung	y = 0.1418x + 2.1413	0.9953	5.01–15,030.00	5.01
Kidney	y = 0.1785x + 2.8676	0.9961	5.01–15,030.00	5.01
Stomach	y = 0.2974x + 4.7142	0.9957	5.01–15,030.00	5.01
Intestines	y = 0.1583x + 2.6446	0.9967	5.01–15,030.00	5.01
Bladder	y = 0.1432x + 2.2233	0.9954	5.01–15,030.00	5.01
Urine	y = 0.0653x + 0.4665	0.9998	5.01–10,020.00	5.01
Feces	y = 0.0981 + 1.5074	0.9996	5.01–1002.00	5.01