Acute and Subchronic Toxicity Profile of a Polyherbal Drug Used in Sri Lankan Traditional Medicine
Table 1
Effect of the polyherbal drug on selected biochemical parameters in healthy rats after 28 days.
Biochemical parameters
Treatments
Healthy control
Hot water extract (1.0 g/kg)
Water : acetone extract (0.5 g/kg)
Water : acetone extract (1.0 g/kg)
Water : acetone extract (1.5 g/kg)
ALT (U/L)
59.66 ± 1.61
61.88 ± 1.17
61.46 ± 1.34
60.02 ± 1.88
62.03 ± 1.62
AST (U/L)
42.43 ± 1.52
44.05 ± 1.20
42.38 ± 1.05
42.69 ± 0.92
42.87 ± 1.40
ALP (U/L)
149.54 ± 1.26
147.78 ± 1.30
147.42 ± 0.94
146.61 ± 1.59
147.29 ± 1.03
Creatinine (mmol/L)
22.16 ± 0.08
23.30 ± 0.07
22.68 ± 0.06
21.96 ± 0.08
22.86 ± 0.08
Urea (mmol/L)
18.98 ± 1.60
19.51 ± 1.17
18.24 ± 1.41
18.35 ± 1.23
19.01 ± 1.37
Total protein (mmol/L)
7.82 ± 0.17
7.86 ± 0.28
7.54 ± 0.24
8.16 ± 0.30
7.95 ± 0.27
TC (mg/dL)
5.18 ± 0.01
4.63 ± 0.01
4.47 ± 0.04
4.02 ± 0.01
3.80 ± 0.02
HDL-C (mg/dL)
3.11 ± 0.03
3.35 ± 0.02
3.24 ± 0.01
3.62 ± 0.01
3.81 ± 0.02
LDL-C (mg/dL)
1.81 ± 0.01
1.75 ± 0.01
1.62 ± 0.02
1.43 ± 0.07
1.24 ± 0.03
TG (mg/dL)
3.35 ± 0.02
3.21 ± 0.06
3.19 ± 0.02
3.04 ± 0.01
2.90 ± 0.01
VLDL-C (mg/dL)
0.67 ± 0.01
0.54 ± 0.02
0.41 ± 0.08
0.49 ± 0.02
0.22 ± 0.01
Fasting glucose (mmol/L)
5.17 ± 0.62
4.63 ± 0.31
4.71 ± 1.02
4.42 ± 0.92
4.32 ± 0.47
Each data point is expressed as mean ± SEM (n = 6/group). ALT: alanine aminotransferase, AST: aspartate aminotransferase, ALP: alkaline phosphatase, TC: serum concentration of total cholesterol, HDL-C: serum concentration of high-density lipoprotein, TG: triacylglyceride, LDL-C: the serum concentration of low-density lipoprotein cholesterol, and VLDL-C: the serum concentration of very low-density lipoprotein cholesterol. Results are significant compared to the control group at < 0.05.
