Acute and Subchronic Toxicity Profile of a Polyherbal Drug Used in Sri Lankan Traditional Medicine

Table 2

Effect of plant extracts on hematological parameters in healthy rats after 28 days.

Hematological parameter	Treatments
	Healthy control rats	Hot water extract (1.0 g/kg)	Water : acetone extract (0.5 g/kg)	Water : acetone extract (1.0 g/kg)	Water : acetone extract (1.5 g/kg)
Basophils (%)	31.13 ± 4.89	30.00 ± 4.53	30.73 ± 3.92	33.23 ± 4.02	32.48 ± 5.01
Eosinophils (%)	2.27 ± 0.27	1.52 ± 0.32	1.63 ± 0.18	1.65 ± 0.41	1.79 ± 0.47
Hemoglobin (g/dL)	14.56 ± 0.23	15.60 ± 0.28	15.70 ± 0.16	15.71 ± 0.39	15.92 ± 0.58
HCT (%)	48.65 ± 1.59	53.72 ± 2.35	52.67 ± 2.93	53.63 ± 1.82	53.32 ± 2.03
Lymphocytes (%)	63.18 ± 4.31	75.72 ± 4.29	71.12 ± 3.60	72.25 ± 4.58	70.89 ± 2.40
MCH (pg)	17.70 ± 0.29	17.40 ± 0.45	17.54 ± 0.34	17.63 ± 0.51	17.35 ± 0.46
MCHC g/dL	30.23 ± 0.43	29.78 ± 0.33	30.05 ± 0.16	29.26 ± 0.82	29.88 ± 0.64
MCV (fl)	58.68 ± 0.19	58.72 ± 0.11	58.82 ± 0.23	60.31 ± 0.34	59.18 ± 0.22
Neutrophil (%)	6.14 ± 2.1	5.53 ± 0.39	5.80 ± 0.20	4.14 ± 0.35	5.52 ± 0.41
Platelet count (/cu.mm)	505200.00 ± 3346	526600.00 ± 4571	510450 ± 3683	430840.00 ± 4123	4859200 ± 3620
RDW (%)	10.33 ± 0.17	10.58 ± 0.11	10.45 ± 0.24	10.54 ± 0.37	10.51 ± 0.26
WBC (/cu.mm)	4980.00 ± 376	6358.00 ± 420	4872.00 ± 297	2859.00 ± 411	5329.00 ± 380
Monocytes (%)	0.71 ± 0.16	0.65 ± 0.10	0.73 ± 0.29	0.75 ± 0.31	0.69 ± 0.40

Each data point is expressed as mean ± SEM (n = 6/group. Results are significant compared to the control group at  < 0.05.