Acute and Subchronic Toxicity Profile of a Polyherbal Drug Used in Sri Lankan Traditional Medicine

Table 3

Effect of the polyherbal drug on relative organ weight of organs in healthy rats after 28 days.

Organ	Relative organ weight
	Healthy control	Hot water extract (1.0 g/kg)	Water : acetone extract (0.5 g/kg)	Water : acetone extract (1.0 g/kg)	Water : acetone extract (1.5 g/kg)
Heart	0.29 ± 0.01	0.29 ± 0.01	0.28 ± 0.01	0.28 ± 0.01	0.28 ± 0.01
Lungs	0.41 ± 0.01	0.45 ± 0.01	0.42 ± 0.01	0.43 ± 0.01	0.43 ± 0.01
Spleen	0.20 ± 0.01	0.20 ± 0.03	0.20 ± 0.02	0.20 ± 0.01	0.20 ± 0.03
Pancreas	0.32 ± 0.01	0.32 ± 0.01	0.32 ± 0.01	0.33 ± 0.01	0.32 ± 0.01
Liver	2.55 ± 0.07	2.45 ± 0.13	2.53 ± 0.08	2.47 ± 0.05	2.49 ± 0.06
Kidney	0.56 ± 0.02	0.57 ± 0.02	0.56 ± 0.01	0.59 ± 0.01	0.56 ± 0.01
Stomach	0.94 ± 0.06	0.74 ± 0.04	0.79 ± 0.06	0.93 ± 0.01	0.84 ± 0.08
Small intestine	1.54 ± 0.06	1.60 ± 0.09	1.62 ± 0.05	1.62 ± 0.06	1.55 ± 0.06

Each data point is expressed as mean ± SEM (n = 6/group). Results are significant compared to the control group at  < 0.05.