| | Term | Number of pathway gene | value |
| | Linoleic acid metabolism | CYP3A4, CYP2J2, CYP2C19, CYP2C9, CYP2C8, CYP2E1, CYP1A2, PLA2G4A, PLA2G1B, PLA2G2A, PLA2G6, PLA2G3, PLA2G4C, PLA2G5 | 1.20E − 11 | | VEGF signaling pathway | PIK3CG, PRKCA, PTGS2, MAPKAPK2, PRKCB, PLA2G4A, KRAS, RAC2, MAPK14, MAPK3, RAC1, PLA2G4C, AKT2 | 2.69E − 06 | | Serotonergic synapse | PRKCA, PLA2G4A, APP, CYP2J2, KRAS, CYP2C19, PTGS2, CYP2C9, CYP2C8, CYP2D6, MAPK3, PTGS1, ALOX12B, PRKACA, ALOX5, PLA2G4C, PRKCB | 4.54E − 06 | | Fc epsilon RI signaling pathway | IL4, PIK3CG, PRKCA, PRKCB, PLA2G4A, KRAS, RAC2, MAPK14, MAPK3, RAC1, PLA2G4C, SYK, AKT2 | 8.83E − 06 | | Alpha-linolenic acid metabolism | ACOX1, PLA2G4A, PLA2G2A, PLA2G1B, PLA2G6, PLA2G4C, PLA2G3, PLA2G5 | 3.08E − 05 | | Pancreatic cancer | PIK3CG, KRAS, RAC2, TGFBR1, MAPK3, TGFBR2, RAC1, NFKB1, SMAD2, EGF, TGFB1, AKT2 | 3.17E − 05 | | Chagas disease (American trypanosomiasis) | PIK3CG, CCL3, TGFBR1, TGFBR2, NFKBIA, NFKB1, SMAD2, BDKRB2, CALR, TGFB1, ACE, MAPK14, MAPK3, FAS, AKT2 | 3.98E − 05 | | Metabolism of xenobiotics by cytochrome P450 | CYP3A4, CYP2A13, CYP3A5, CYP1B1, CYP1A1, CYP2B6, CYP2C9, CYP2D6, CYP2A6, CYP2E1, CYP1A2, AKR1C1 | 1.09E − 04 | | Sphingolipid signaling pathway | PRKCA, PIK3CG, SGMS2, CERS5, NFKB1, SGMS1, BDKRB2, PRKCB, KRAS, RAC2, MAPK14, MAPK3, RAC1, ABCC1, AKT2 | 1.93E − 04 | | Chemical carcinogenesis | CYP3A4, CYP2A13, CYP3A5, CYP1B1, CYP1A1, CYP2C19, PTGS2, CYP2C9, CYP2C8, CYP2A6, CYP2E1, CYP1A2 | 2.22E − 04 | | Ras signaling pathway | PRKCA, PIK3CG, FGFR4, CSF1, NFKB1, PRKCB, PLA2G4A, KRAS, RAC2, RAC1, MAPK3, PLA2G1B, PLA2G2A, PLA2G6, PRKACA, FGF1, PLA2G3, PLA2G4C, EGF, PLA2G5, AKT2 | 4.17E − 04 | | Osteoclast differentiation | PIK3CG, NCF2, TGFBR1, CSF1, CREB1, PPARG (PPARP), TGFBR2, NFKBIA, NFKB1, TGFB1, MAPK14, MAPK3, RAC1, AKT2, SYK | 4.83E − 04 | | Colorectal cancer | PIK3CG, KRAS, RAC2, TGFBR1, MAPK3, TGFBR2, RAC1, SMAD2, TGFB1, AKT2 | 5.51E − 04 | | FoxO signaling pathway | PIK3CG, TGFBR1, TGFBR2, SMAD2, SIRT1, TGFB1, G6PC, KRAS, MAPK14, MAPK3, PRKAA1, CAT, PRKAA2, EGF, AKT2 | 6.08E − 04 | | Retinol metabolism | CYP3A4, CYP3A5, DGAT1, CYP1A1, CYP2B6, CYP2C9, CYP2C8, HSD17B6, CYP2A6, CYP1A2 | 7.00E − 04 | | MAPK signaling pathway | PRKCA, FGFR4, TGFBR1, TGFBR2, NFKB1, HSPA1A, HSPA1B, MAPKAPK2, TGFB1, PRKCB, PLA2G4A, KRAS, RAC2, MAPK14, RAC1, MAPK3, PRKACA, FAS, FGF1, PLA2G4C, EGF, AKT2 | 7.04E − 04 | | Drug metabolism-cytochrome P450 | CYP3A4, CYP3A5, CYP2C19, CYP2B6, CYP2C9, CYP2C8, CYP2D6, CYP2A6, CYP2E1, CYP1A2 | 0.001095 | | B Cell receptor signaling pathway | PIK3CG, KRAS, RAC2, MAPK3, RAC1, CD81, NFKBIA, NFKB1, AKT2, SYK | 0.001218 | | Hepatitis C | PIK3CG, PPARA, LDLR, RXRA, NFKBIA, NFKB1, KRAS, MAPK14, MAPK3, CD81, SCARB1, EGF, AKT2, NR1H3 | 0.001755 | | Influenza A | PRKCA, PIK3CG, IL18, FDPS, NFKBIA, NLRX1, HSPA1A, NFKB1, HSPA1B, NLRP3, PRKCB, MAPK14, MAPK3, PYCARD, FAS, AKT2 | 0.002805 |
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