Antistaphylococcal Activity of Extracts, Fractions, and Compounds of Acacia polyacantha Wild (Fabaceae)

Table 3

MICs (μg/mL) of isolated compounds from leaves and stem barks of Acacia polyacantha.

Compounds, MICs, and MBCs (in parentheses) in μg/mL
Bacteria	2	3	4	5	6	7	9	10
ATCC25923	512 (-)	128 (-)	32	—	—	—	—	512 (-)
MRSA 3	256 (-)	32 (-)	16	—	—	256 (-)	—	256 (-)
MRSA 4	—	64 (-)	64	—	—	—	—	512 (-)
MRSA 6	—	64 (-)	32 (512)	—	—	128 (-)	—	256 (-)
MRSA 8	512 (-)	128 (-)	128	—	256 (-)	256 (-)	—	512 (-)
MRSA 9	256 (-)	64 (-)	32 (512)	—	—	64 (-)	—	512 (-)
MRSA 11	256 (-)	64 (-)	16 (512)	—	—	256 (-)	—	256 (-)
MRSA 12	256 (-)	128 (-)	32 (256)	—	—	512	—	512 (-)
MSSA 01	512 (-)	32 (-)	16	—	—	256 (-)	—	256 (-)
SA 01	128 (-)	128 (-)	64	512 (-)	—	256 (-)	512 (-)	32 (-)
SA 07	512 (-)	64 (-)	—	—	—	—	—	64 (-)
SA 18	—	64 (-)	64	512 (-)	—	512 (-)	512 (-)	16 (-)
SA 23	—	128 (-)	16	—	—	128 (-)	—	512 (-)
SA 88	256 (-)	512 (-)	—	—	—	—	—	128 (-)

(-): ≥512 μg/mL; MIC: minimum inhibitory concentration; MBC: minimum bactericidal concentration; MRSA: methicillin-resistant Staphylococcus aureus; SA: Staphylococcus aureus; MSSA: methicillin susceptible Staphylococcus aureus; 2: β-amyrin; 1: stigmasterol; 3: 3-O-méthyl-_D-chiro-inositol; 4: epicatechin; 5: quercetin-3-O-glucoside; 6: 3-O-[β-_D-xylopyranosyl-(1 ⟶ 4)-β-_D-galactopyranosyl]-oleanolic acid; 7: 3-O-[β galactopyranosyl-(1 ⟶ 4)-β-D-galactopyranosyl]-oleanolic acid; 8: Lupeol; 9: 2,3-dihydroxypropyltetracosanoate; 10: methyl gallate. Compounds 1 and 8 were not active on all tested bacteria.