Research Article

Pharmacokinetics of Bismuth following Oral Administration of Wei Bi Mei in Healthy Chinese Volunteers

Table 1

Pharmacokinetic parameters of bismuth after a single oral dose of Wei Bi Mei (mean ± SD, n = 7).

ParameterCmax (ng/mL)tmax (h)t1/2 (h)Vd (×103 L)AUC0–24 (h ng/mL)AUC0-∞ (h ng/mL)MRT (0-t) (h)

0.85 ± 0.552.29 ± 0.769.98 ± 5.13196.47 ± 98.798.33 ± 5.428.43 ± 5.0811.82 ± 6.78

Cmax, peak concentration; tmax, time to peak concentration; t1/2, half-life; Vd, volume of distribution; AUC, area under the curve; MRT, mean residence time.