Pharmacokinetics of Bismuth following Oral Administration of Wei Bi Mei in Healthy Chinese Volunteers

<table class="table-group" id="tab2"><tr><td><table class="table"><tr><td class="thead-hr" colspan="8"><hr/></td></tr><tr class="thead"><td class="align_left">Parameter</td><td class="align_center">Cmax (ng/mL)</td><td class="align_center">tmax (d)</td><td class="align_center">t1/2 (d)</td><td class="align_center">Vd (×103 L)</td><td class="align_center">AUC0-t (d ng/mL)</td><td class="align_center">AUC0-∞ (d ng/mL)</td><td class="align_center">MRT (0-t) (d)</td></tr><tr><td class="thead-hr" colspan="8"><hr/></td></tr><tr><td class="align_left"> </td><td class="align_center">2.25 ± 1.18</td><td class="align_center">2.0</td><td class="align_center">20.04 ± 10.65</td><td class="align_center">22.97 ± 9.82</td><td class="align_center">55.26 ± 32.01</td><td class="align_center">58.68 ± 36.64</td><td class="align_center">21.69 ± 3.95</td></tr><tr class="table-tr"><td colspan="8"><hr class="tbody-hr"/></td></tr></table></td></tr><tr class="table-fn"><td><div>Cmax, peak concentration; tmax, time to peak concentration; t1/2, half-life; Vd, volume of distribution; AUC, area under the curve; MRT, mean residence time. </div></td></tr></table>

<div>Pharmacokinetic parameters of bismuth following multiple-dose Wei Bi Mei administration (mean ± SD, n = 7).</div>

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Table 2

Table 2: Pharmacokinetics of Bismuth following Oral Administration of Wei Bi Mei in Healthy Chinese Volunteers 